{"id":62228,"date":"2022-12-07T11:04:23","date_gmt":"2022-12-07T17:04:23","guid":{"rendered":"https:\/\/lafeber.com\/vet\/?p=62228"},"modified":"2025-07-27T09:29:22","modified_gmt":"2025-07-27T14:29:22","slug":"rabbit-hemorrhagic-disease-and-vaccination","status":"publish","type":"post","link":"https:\/\/lafeber.com\/vet\/rabbit-hemorrhagic-disease-and-vaccination\/","title":{"rendered":"Rabbit Hemorrhagic Disease and Vaccination"},"content":{"rendered":"
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Photo credit: David-O via Flickr Creative Commons<\/small><\/p><\/div>\n

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Abstract<\/h2>\n

Rabbit hemorrhagic disease<\/a> (RHD) is a usually fatal disease affecting almost exclusively lagomorphs caused by the rabbit hemorrhagic disease viruses (RHDV). While initial outbreaks of RHDV-1 occurred in Europe and Asia, RHDV-2 has emerged and spread across the globe within the span of the last 10 years. RHDV-2 has resulted in major outbreaks of RHD in wild and domestic rabbits in Washington State and the North American Southwest (USA and Mexico) since 2020.<\/p>\n

RHDV-2 causes a severe necrotizing hepatitis in lagomorphs that results in secondary disseminated intravascular coagulation and death. Death is often peracute and other signs may not be recognized prior to death. RHDV-2 is a calicivirus that is environmentally stable and transmitted primarily by fomites via the oral-fecal route. Due to the ease in inadvertent exposure via fomites and the seriousness of the disease, vaccination is recommended as the primary means to prevent infection. Initial importation of unapproved European killed vaccines was allowed for affected states only and were difficult and expensive to acquire.<\/p>\n

Medgene Labs has recently received United States Department of Agriculture Center for Veterinary Biologics<\/span><\/span> (USDA-CVB) emergency use approval for their inactivated recombinant subunit protein vaccine, increasing availability and ease of acquiring vaccines across the country. Due to vaccine developments, vaccination against RHDV-2 for domestic rabbits is now widely available and strongly encouraged.<\/p>\n

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Outline<\/h2>\n\n\n\n
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  • History of RHDV\n
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    1. RHDV general information<\/li>\n
    2. Initial emergence of RHDV-1 and RHDV-2<\/li>\n
    3. North American outbreak and progression<\/li>\n
    4. RHDV-1, RHDV-2 pathological differences<\/li>\n<\/ol>\n<\/li>\n<\/ul>\n
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      • Pathology\n
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        1. Transmission<\/li>\n
        2. Clinical disease<\/li>\n
        3. Pathophysiology<\/li>\n
        4. Diagnostics<\/li>\n
        5. Case study<\/li>\n<\/ol>\n<\/li>\n<\/ul>\n
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          • Vaccines<\/li>\n<\/ul>\n
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            1. \n
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              1. European vaccines\n
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                1. Overview<\/li>\n
                2. Adverse Events<\/li>\n<\/ol>\n<\/li>\n
                3. Medgene vaccine\n
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                  1. Overview<\/li>\n
                  2. Safety<\/li>\n
                  3. Adverse events<\/li>\n
                  4. Label requirements<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/td>\n
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Photo: Alex via Flickr Creative Commons<\/p><\/div>\n

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About the presenter<\/h2>\n

Dr. Amanda Jones is a consultant for Medgene Labs, and a supervising veterinarian for the Medgene Labs Texas Field Safety Site. Dr. Jones is also the owner of Central Texas Rabbit Herd Management in Killeen, Texas and an associate veterinarian for Animal Emergency Services of Killeen. Dr. Jones is a 2014 Cum Laude graduate of the Texas A&M College of Veterinary Medicine and\u2026 [MORE<\/a>]<\/p>\n

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Webinar recording<\/h2>\n