This non-interactive, RACE-approved webinar recording by Dr. Brenna Fitzgerald reviews avian ganglioneuritis (formerly proventricular dilatation disease or PDD) and avian bornavirus, which are extremely complex and potentially confusing topics. This lecture begins with what is currently known (including varying viewpoints among the scientific community) and emphasizes what clinicians need to know about this disease, including diagnostic and treatment options. The latest discoveries reported in the literature are discussed to help guide best practices . . .
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References
Leal de Araujo J, Hameed SS, Tizard I, et al. Cardiac lesions of natural and experimental infection by parrot bornaviruses. J Comp Pathol. 2020;174:104-112. doi: 10.1016/j.jcpa.2019.11.008. Epub 2019 Dec 23. PMID: 31955795.
Leal de Araujo J, Tizard I, Guo J, et al. Are anti-ganglioside antibodies associated with proventricular dilatation disease in birds? PeerJ. 2017;5:e3144. doi: 10.7717/peerj.3144. PMID: 28413724; PMCID: PMC5390765.
Gancz AY, Kistler AL, Greninger AL, et al. Experimental induction of proventricular dilatation disease in cockatiels (Nymphicus hollandicus) inoculated with brain homogenates containing avian bornavirus 4. Virol J. 2009;6:100. doi: 10.1186/1743-422X-6-100. PMID: 19589169; PMCID: PMC2717941.
Hameed SS, Guo J, Tizard I, Shivaprasad HL, Payne S. Studies on immunity and immunopathogenesis of parrot bornaviral disease in cockatiels. Virology. 2018;515:81-91. doi: 10.1016/j.virol.2017.12.007. Epub 2017 Dec 20. PMID: 29274528.
Kistler AL, Gancz A, Clubb S, et al. Recovery of divergent avian bornaviruses from cases of proventricular dilatation disease: identification of a candidate etiologic agent. Virol J. 2008;5:88. doi: 10.1186/1743-422X-5-88. PMID: 18671869; PMCID: PMC2546392.
Link J, Herzog S, Gartner AM, et al. Factors influencing vertical transmission of psittacine bornavirus in cockatiels (Nymphicus hollandicus). Viruses. 2022;14(12):2721. doi: 10.3390/v14122721. PMID: 36560725; PMCID: PMC9785454.
Olbert M, Römer-Oberdörfer A, Herden C, et al. Viral vector vaccines expressing nucleoprotein and phosphoprotein genes of avian bornaviruses ameliorate homologous challenge infections in cockatiels and common canaries. Sci Rep. 2016;6:36840. doi: 10.1038/srep36840. PMID: 27830736; PMCID: PMC5103271.
Rall I, Amann R, Malberg S, Herden C, Rubbenstroth D. Recombinant modified vaccinia virus Ankara (MVA) vaccines efficiently protect cockatiels against parrot bornavirus infection and proventricular dilatation disease. Viruses. 2019;11(12):1130. doi: 10.3390/v11121130. PMID: 31817690; PMCID: PMC6950018.
Runge S, Olbert M, Herden C, et al. Viral vector vaccines protect cockatiels from inflammatory lesions after heterologous parrot bornavirus 2 challenge infection. Vaccine. 2017;35(4):557-563. doi: 10.1016/j.vaccine.2016.12.022. Epub 2016 Dec 22. PMID: 28017426.
Ouyang N, Storts R, Tian Y, et al. Histopathology and the detection of avian bornavirus in the nervous system of birds diagnosed with proventricular dilatation disease. Avian Pathol. 2009;38(5):393-401. doi: 10.1080/03079450903191036. PMID: 19937526.
Rossi G, Dahlhausen RD, Galosi L, Orosz SE. Avian ganglioneuritis in clinical practice. Vet Clin North Am Exot Anim Pract. 2018;21(1):33-67. doi: 10.1016/j.cvex.2017.08.009. PMID: 29146031.
Rubbenstroth D, Briese T, Dürrwald R, et al. Ictv Report Consortium. ICTV Virus Taxonomy Profile: Bornaviridae. J Gen Virol. 2021;102(7):001613. doi: 10.1099/jgv.0.001613. PMID: 34227935; PMCID: PMC8491894.
Rubbenstroth D. Avian Bornavirus Research-A Comprehensive Review. Viruses. 2022;14(7):1513. doi: 10.3390/v14071513. PMID: 35891493; PMCID: PMC9321243.
Schmidt RE, Reavill DR, Phalen DN. Pathology of Pet and Aviary Birds, Second Edition. Ames: Wiley & Blackwell; 2015. ISBN: 978-1-118-82809-0.
Fitzgerald B. A clinician’s perspective on avian ganglioneuritis and avian bornavirus. LafeberVet web site. Jan 17, 2023. Available at https://lafeber.com/vet/a-clinicians-perspective-on-avian-ganglioneuritis-and-avian-bornavirus/