Douglas Mader, MS, DVM, DABVP (Canine/Feline Practice), DABVP (Reptile/Amphibian Practice), DECZM (Herpetology) presented this live, interactive webinar. View the RACE-approved webinar recording, then take and pass the brief post-test to earn 1 continuing education credit. Effective therapeutic management of reptile patients requires strict attention to the Preferred Optimal Temperature Zone (POTZ). Warming patients to their POTZ ensures predictable pharmacologic responses, as reptiles at ideal temperatures demonstrate significantly improved drug absorption and metabolism compared with hypothermic individuals. Hydration status and appropriate route selection also influence therapeutic success in reptile medicine. Various routes of drug and fluid administration are explored, from subcutaneous and intracoelomic to intramuscular, intravenous, and intraosseous routes of injection.