Coronaviruses are a large group of viruses named for the crown-like spike proteins on their surface. Coronaviruses cause disease in humans and animals, often circulating among camels, cats, and bats. Ferrets are susceptible to infection by the SARS coronavirus (SARS-COv-1), but pathogenicity and host susceptibility can differ based on the viral infective dose and laboratory SARS coronavirus strain. Studies are ongoing to investigate the respiratory pathology and transmission of COVID-19 (SARS-CoV-2) in experimental ferrets.
What determines the viral host range?
One of the critical determinants of viral host range is the interaction between the coronavirus spike (S) protein (Fig 1) and the host cell receptor. Angiotensin-converting enzyme 2 (ACE2), a receptor for the attachment and uptake of the coronavirus that caused Severe Acute Respiratory Syndrome (SARS-CoV-1), is widely expressed […]